Highest Cardiovascular Mortality for Normal BMI, Central Obesity

Last Updated: August 29, 2012.
Mayo Clinic:

Mortality higher for those with normal BMI, high waist-to-hip ratio than for obese based on BMI

Individuals with a high waist-to-hip ratio and normal body mass index have the worst cardiovascular mortality, according to a study presented at the annual European Society of Cardiology Congress, held from Aug. 25 to 29 in Munich…

Consuming More Fats and Wine May Reduce Central Obesity

From: NaturalStandard.com

According to a recent study, a diet high in fat and wine may reduce central obesity.

Central obesity (increased waist circumference) may potentially increase the risk for certain diseases, such as diabetes, high cholesterol and cardiovascular disease.

In the study, researchers evaluated data from the dietary questionnaires of 2641 women from the Framingham Offspring-Spouse Study. The women were all healthy and followed for a total of seven years. The women were separated into five groups based on the foods they consumed the most: Heart Healthier, Lighter Eating, Wine and Moderate Eating, Higher Fat, and Empty Calorie.

Only the Wine and Moderate Eating group and the Higher Fat group were associated with lower abdominal obesity. The Wine and Moderate Eating group consumed a greater quantity of high-fat dairy, eggs, organ meat and wine. The Higher Fat group consumed more sweets, vegetable fats and animal fats.

The authors noted a limitation of their study was the small sample size. Furthermore, they cautioned that central obesity is only one measure of health. More research is needed to further evaluate these findings.

Research into the Role of Insulin and IGF in Cancers

Unraveling the Obesity-Cancer Connection
Gary Taubes

Insulin, a hormone produced in the pancreas, is more commonly known for its role in diabetes. But its reputation may be changing. Insulin and a related hormone known as insulin-like growth factor (IGF) are now at the center of a growing wave of research around the world aimed at elucidating what many scientists consider to be their critical role in fueling a wide range of cancers. Elevated levels of insulin and IGF are also the leading candidates to explain a significant correlation in epidemiology that has gained attention over the past 30 years: Obese and diabetic individuals have a far higher risk than lean healthy people of getting cancer, and when they do get it, their risk of dying from it is greater. And now that obesity and diabetes rates are skyrocketing, the need to understand this link has become far more urgent.

Women in the Workplace… It Pays to be Thin


From: CNBC

How do people’s weight effect them in the workplace?

Very thin women = higher pay {avg. $15,000 more)
More weight = smaller salary


Just the opposite…


That’s really not fair, but you are basically being shut out of a performance based salary by your weight. ~ Gigi

How to Keep Muscles Young: Eat Less Food

Technology Review

How to Keep Muscles Young: Eat Less Food
Caloric restriction and exercise slow muscle decline in mice.
By Emily Singer

The connections between your nerves and muscle deteriorate with age–a phenomenon that may help explain the serious loss of muscle that often strikes old people. New evidence suggests that caloric restriction–a nutritionally complete but low-calorie diet–could help prevent these changes. According to a study published this week, a very-low-calorie diet, and to a lesser extent exercise, can prevent or slow some aspects of muscle decline in aging mice.

Here’s the article…

Obesity: How Intestinal Bacteria May Cause Weight Gain

Obesity: How Intestinal Bacteria May Cause Weight Gain – Yahoo! News

Obesity: How Intestinal Bacteria May Cause Weight Gain

If you’re fighting the battle of the bulge, most of your attention – and frustration – is probably aimed at your midsection. It makes sense, since that’s where the extra pounds tend to gravitate, especially with the creep of middle age, piling on to form that dreaded spare tire.
But a growing body of research suggests there’s another, less visible reason to focus on your gut if you want to lose weight. Scientists led by Andrew Gewirtz at Emory University reveal that your intestines harbor a universe of bacteria – the so-called gut microbiota – that may play an important role in whether your body will store the food you eat as extra pounds.

Here’s the article…

Impact of Abdominal Obesity on Incidence of Adverse Metabolic Effects Associated With Antihypertensive Medications — Cooper-DeHoff et al. 55 (1): 61 — Hypertension

Impact of Abdominal Obesity on Incidence of Adverse Metabolic Effects Associated With Antihypertensive Medications — Cooper-DeHoff et al. 55 (1): 61 — Hypertension

Impact of Abdominal Obesity on Incidence of Adverse Metabolic Effects Associated With Antihypertensive Medications
Rhonda M. Cooper-DeHoff; Sheron Wen; Amber L. Beitelshees; Issam Zineh; John G. Gums; Stephen T. Turner; Yan Gong; Karen Hall; Vishal Parekh; Arlene B. Chapman; Eric Boerwinkle; Julie A. Johnson

From the Colleges of Pharmacy (R.M.C.-D., S.W., J.G.G., Y.G., J.A.J.) and Medicine (R.M.C.-D., J.G.G., K.H., J.A.J.) and Center for Pharmacogenomics (R.M.C.-D., S.W., J.G.G., Y.G., J.A.J.), University of Florida, Gainesville, Fla; School of Medicine (A.L.B.), University of Maryland, Baltimore, Md; US Food and Drug Administration (I.Z.), Silver Spring, Md; Mayo Clinic College of Medicine (S.T.T.), Rochester, Minn; Morehouse School of Medicine (V.P.), Atlanta, Ga; School of Medicine (A.B.C.), Emory University, Atlanta, Ga; Human Genetics Center and Institute of Molecular Medicine (E.B.), University of Texas at Houston, Houston, Tex.

Correspondence to Rhonda M. Cooper-DeHoff, Department of Pharmacotherapy and Translational Research, College of Pharmacy, University of Florida, 1600 SW Archer Rd, Box 100486, Gainesville, FL 32610-0486. E-mail [email protected]

We assessed adverse metabolic effects of atenolol and hydrochlorothiazide among hypertensive patients with and without abdominal obesity using data from a randomized, open-label study of hypertensive patients without evidence of cardiovascular disease or diabetes mellitus. Intervention included randomization to 25 mg of hydrochlorothiazide or 100 mg of atenolol monotherapy followed by their combination. Fasting glucose, insulin, triglycerides, high-density lipoprotein cholesterol, and uric acid levels were measured at baseline and after monotherapy and combination therapy. Outcomes included new occurrence of and predictors for new cases of glucose ≥100 mg/dL (impaired fasting glucose), triglyceride ≥150 mg/dL, high-density lipoprotein ≤40 mg/dL for men or ≤50 mg/dL for women, or new-onset diabetes mellitus according to the presence or absence of abdominal obesity. Abdominal obesity was present in 167 (58%) of 395 patients. Regardless of strategy, in those with abdominal obesity, 20% had impaired fasting glucose at baseline compared with 40% at the end of study (P<0.0001). Proportion with triglycerides ≥150 mg/dL increased from 33% at baseline to 46% at the end of study (P<0.01). New-onset diabetes mellitus occurred in 13 patients (6%) with and in 4 patients (2%) without abdominal obesity. Baseline levels of glucose, triglyceride, and high-density lipoprotein predicted adverse outcomes, and predictors for new-onset diabetes mellitus after monotherapy in those with abdominal obesity included hydrochlorothiazide strategy (odds ratio: 46.91 [95% CI: 2.55 to 862.40]), female sex (odds ratio: 31.37 [95% CI: 2.10 to 468.99]), and uric acid (odds ratio: 3.19 [95% CI: 1.35 to 7.52]). Development of adverse metabolic effect, including new-onset diabetes mellitus associated with short-term exposure to hydrochlorothiazide and atenolol was more common in those with abdominal obesity. Key Words: atenolol • hydrochlorothiazide • abdominal obesity • metabolic syndrome • new-onset diabetes mellitus • hypertension
Here’s the article…

Obesity In Mid-Life Linked To Risk Of Frailty

Obesity among middle-age people increases the risk of illness and death later in life, according to Finnish researchers.

A team of researchers studied more than 1,000 men from age 25 to mid-70s and found that those who were overweight during their 40s followed by a period of weight loss were more susceptible to illness and death as they got older.

Writing in the European Heart Journal, researchers said that while obesity has been linked to risk of heart disease, other studies have shown that being overweight can actually help in situations of heart failure.

Posted on: Monday, 25 May 2009, 11:23 CDT

Here’s the article…

Microbe Composition In Gut May Hold Key To One Cause Of Obesity

Microbe Composition In Gut May Hold Key To One Cause Of Obesity

Microbe Composition In Gut May Hold Key To One Cause Of Obesity ScienceDaily (Jan. 20, 2009) — Biodesign Institute in collaboration with colleagues at the Mayo Clinic, Arizona, and the University of Arizona, reveal a tantalizing link between differing microbial populations in the human gut and body weight among three distinct groups: normal weight individuals, those who have undergone gastric bypass surgery, and patients suffering the condition of morbid obesity—a serious, often life-threatening condition associated with diabetes, cardiovascular disease, cancer and psychosocial disorders. Obesity affects around 4 million Americans and, each year, some 300,000 die from obesity-related illness.

Here’s the article…